Nicktoons Unite! brings together the most devious minds in the Nicktoons universe, and it's up to you to fight them! Professor Calamitous has pulled together Plankton, Vlad, and Crocker to form a group known as The Evil Syndicate. The wicked foursome have begun to wreak havoc throughout Retroville, Amity Park, Dimmsdale, and Bikini Bottom in an attempt to take over the world. Not to be outsmarted, Jimmy Neutron calls upon his own band of Nicktoons!